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In our experience, of 295 patients treated with danazol , 88 30 complained of significant adverse events and 43 had to stop treatment.

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the combination of danazol and warfarin should be avoided because danazol can decrease the hepatic synthesis of coagulant factors which can greatly increase the chances of excessive bleeding when used together with platelet inhibitors, thrombolytic agents, and anticoagulants.

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