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Cephalexin has a relatively narrow-spectrum and therefore is preferable to the broader-spectrum cephalosporins such as cefaclor, cefuroxime, cefixime, and cefpodoxime.

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we were able to explain and reproduce the observed boom-and-bust trend of cefixime resistance by modelling both the fitness cost and the fitness benefit of resistant strains relative to susceptible strains.

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if cefixime were used to treat more than 58 of cases, then the level of cefixime resistance would become greater than 50 at the end of the 8-year simulation period, and if cefixime were used to treat all cases, resistance would be close to 100 .

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cefixime is active in vitro against both b-lactamase- and non-b-lactamase-producing moraxella formerly branhamella catarrhalis, and the mic90 of the drug reported for this organism is 0.

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cefixime may pass into breast milk and could harm a nursing baby.


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