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In the eutract 2009-012499-28 study, which enrolled 20 virologically suppressed immunologic non-responders, hydroxychloroquine was reported as well tolerated in all participants, except for 1 participant who experienced maculopapular exanthema after 10 days of treatment.

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hydroxychloroquine plaquenil is the most commonly prescribed because it is generally believed to cause fewer side effects; chloroquine aralen has a reputation for more serious side effects, but it may be prescribed in situations where hydroxychloroquine cannot be used.

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