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decreased absorption due to increased gastric ph griseofulvin ketoconazole itraconazole iron salts vitamin b12 cefpodoxime enoxacin increased absorption due to increased gastric ph nifedipine procardia digoxin drug level increases specific to prilosec cyp 450 carbamazepine tegretol diazepam valium phenytoin dilantin warfarin coumadin methotrexate drug level decreases specific to prevacid cyp 450 theophylline drug lowered efficacy specific to prilosec clopidogrel plavix increased major coronary events occurred within one year of ptca attributed to omeprazole s interaction with clopidogrel gaglia 2010 am j cardiol 105 6 833-8 pubmed pantoprazole protonix does not lower clopidogrel efficacy juurlink 2009 cmaj 180 7 713-8 pubmed avoid omeprazole following ptca and coronary stenting consider h2 blocker or pantoprazole instead as of 2015, no consistent drug interaction between proton pump inhibitors and clopidogrel melloni 2015 circ cardiovasc qual outcomes 8 1 47-55 pmid 25587094 pubmed .

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