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Many drugs, including most drugs effective in the treatment of major depressive disorder paroxetine, other ssris, and many tricyclics , are metabolized by the cytochrome p 450 isozyme cyp2d6.

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in a fixed-dose study comparing placebo and 20 and 40 mg of paroxetine in the treatment of gad, for most of the adverse events, there was no clear relationship between adverse events and the dose of paroxetine to which patients were assigned, except for the following adverse events asthenia, constipation, and abnormal ejaculation.

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patients should be advised of the following issues and asked to alert their prescriber if these occur while taking paroxetine.

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social anxiety disorder the most commonly observed adverse events associated with the use of paroxetine incidence of 5 or greater and incidence for paxil at least twice that for placebo, derived from table 3 were sweating, nausea, dry mouth, constipation, decreased appetite, somnolence, tremor, libido decreased, yawn, abnormal ejaculation, female genital disorders, and impotence.

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since the introduction of immediate-release paroxetine hydrochloride in the united states, 342 spontaneous cases of deliberate or accidental overdosage during paroxetine treatment have been reported worldwide circa 1999 .

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