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Olanzapine is primarily metabolized by glucuronidation and cytochrome p450 cyp oxidation via cyp1a2 and cyp2d6.

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3 in another trial, 361 patients meeting dsm iv criteria for a manic or mixed episode of bipolar disorder who had responded during an initial open label treatment phase for about two weeks, on average, to olanzapine 5 to 20 mg day were randomized to either continuation of olanzapine at their same dose n 225 or to placebo n 136 , for observation of relapse.

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its purpose was to compare the effectiveness of three atypical antipsychotic drugs, each of which had already been approved by the fda seroquel quetiapine , zyprexa olanzapine , and risperdal risperidone.

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