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Therefore, any abrupt dosage reduction or withdrawal of sinemet should be carefully observed, particularly in patients who are also receiving neuroleptics.

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the efficacy of sinemet retard was established in a randomized, double-blind,double-dummy, active-controlled, parallel group, 12-week study study1 in patients with advanced parkinson s disease who were levodopa-responsiveand had persistent motor fluctuations while on treatment with oralimmediate-release carbidopa-levodopa and other parkinson s diseasemedications.

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patients with lewy body dementia or parkinson s disease with dementia can have hallucinations regardless of the medications that they take, but sinemet can make the hallucinations more common and worse.

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